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These patients follow virologic failure/toxicity management guidelines as detailed in the protocol. Patients coenrolling in A5116: Patients are studied on their assigned A5116 omega 3 fatty acid fish oil antiretroviral regimens with medication as provided by A5116. Those randomized in A5116 to the NRTI-sparing regimen of EFV and LPV/r identical to that offered by A5133 will be omega 3 fatty acid fish oil assessed together with patients who entered A5133 as a stand-alone study. Individuals assigned in A5116 to the continued NRTI arm of 2NRTIs omega 3 fatty acid fish oil plus EFV are enrolled into a separate observational arm of A5133. The impact of continued NRTI therapy on liver histology is assessed in this observational arm. Virologic failure/toxicity management is in accordance with the A5116 protocol. The definition of virologic failure in A5116 is identical to the definition used in A5133. Arm 1 consists of patients assigned to an NRTI-sparing regimen without evidence of HCV coinfection.
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