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fatty liver disease (NAFLD)refers to a wide spectrum of liver disease ranging from simple fatty liver(steatosis), to nonalcoholic steatohepatitis (NASH), to cirrhosis (irreversible,advanced scarring of the liver). All of the stages of NAFLD have fatty acid ester in common theaccumulation of fat (fatty infiltration) fatty acid ester in the liver cells (hepatocytes). InNASH, the fat accumulation is associated with varying degrees of inflammation(hepatitis) and scarring (fibrosis) of the liver.The term nonalcoholic is used because NAFLD and NASH occur in individuals whodo not consume excessive amounts of alcohol. Yet, in many respects, thehistological picture of NAFLD (when we look fatty acid ester at a biopsy piece of liver under themicroscope) is similar to what can be seen in liver disease that is due toexcessive intake of alcohol.
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