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Macrovesicular fat is deposited in large vacuoles in hepatocytes; such accumulation pushes the nucleus toward the wall of the cell. In contrast, microvesicular fat is deposited throughout the cytoplasm; in this instance, the nucleus fatty girl lyrics retains its central location. Macrovesicular fat deposition typically occurs in NAFLD and alcoholic liver disease, whereas microvesicular fat deposition occurs in Reye syndrome and acute fatty liver of pregnancy and as a possible adverse fatty girl lyrics effect of certain medications, such as valproic acid. 3. What is the underlying pathologic mechanism that causes NAFLD? The underlying cause is unknown, but it appears to be related to a fatty girl lyrics problem with fat metabolism. The condition is associated with type 2 diabetes mellitus, obesity, total parenteral nutrition involving fat emulsions, rapid weight loss, and hyperlipidemia-all of which are characterized by impaired fat metabolism.
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