PNF occurred in 7 4th international workshop on adverse drug reactions and lipodystrophy in hiv plump moms

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PNF occurred in 7 of 8 livers with plump moms severe fatty infiltration (3), hydropic degeneration (3), and centrilobular necrosis (1). A fourth liver with hydropic degeneration and poor function ultimately failed requiring retransplantation 8 weeks later. Analysis of liver function revealed progressive elevation in aspartate-aminotransferase, alanine-aminotransferase, lactate dehydrogenase, and serum ammonia (NH3) with increasing degrees of fatty infiltration. Donor age and weight was also found plump moms to be significantly higher in livers with fatty infiltration. This study suggests that donor liver biopsies demonstrating normal histology or minimal-to-moderate fatty infiltration plump moms function adequately, but that donor livers with severe fatty infiltration or hydropic degeneration function poorly and should not be transplanted.PMID:
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