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As it turns out, the organizations brain watches not for rising leptin levels as a sign of fullness, but for lowering leptin levels as a red alert for starvation - hence the Punjabi cousins' leptinless gorging. Evolution has laid down multiple systems for protecting us against hunger; it has not given us much to protect against plenty.The appetite pathway, along which the chemical couriers travel with their 'I am hungry' messages, organizations is not a single clear track through organizations the tangled forest of genes and proteins, but a winding, forking route that intersects, in ways our minds may not be capable of grasping, with a myriad other pathways carrying equally vital information. Scientists can dig a pit somewhere along the pathway to stop a hunger courier reaching its destination; but what if the courier is carrying more than one message? The tale of the depressed patients in the sibutramine trial who took a pill to make them feel less sad and ended up still depressed but thinner shows both scientists' lack of knowledge and the way in which mind and body are entwined.
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