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The reviewer agreement among the three abdominal radiologists who were unaware of the consensus systemic carnitinedeficiency results was evaluated using kappa statistics [11]. To further understand the effect of patient age and lesion size on the agreement in the blinded review, we arranged the studies in two groups. The "agreed" group included patients for whom all three radiologists had consensus as positive or negative findings for focal fatty infiltration of the liver; the "disagreed" group included patients for whom no consensus readings were achieved by three radiologists in their independent evaluations. We compared differences in patient age and lesion systemic carnitinedeficiency size between the two groups for positives and negatives using Wilcoxon's rank sum test. The effect of age on prevalence of focal fatty infiltration of the liver was evaluated using a logistic regression analysis with 95% confidence interval (CI) of odds ratios.
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