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Salicylate use during an acute influenza illness increases risk for developing Reye's syndrome by as much as 35fold. Thus, the use of salicylates in persons < 18 yr, except for a few specific diseases (eg, juvenile RA, Kawasaki plump wife syndrome), is considered potentially dangerous. However, plump wife it is unclear whether the decrease in incidence of Reye's syndrome is due exclusively to decreased use of salicylates in children or to other factors. Pathology With light microscopy, uniform intracytoplasmic panlobular microvesicular fatty infiltration of the liver is seen, which stains with oil-red-O (a Sudan dye) on frozen plump wife section. On electron microscopy, sections of liver show mitochondrial injury that varies with the severity of the disease but includes glycogen depletion, smooth endoplasmic reticulum proliferation, peroxisome damage, and mitochondrial matrix swelling. Histologic abnormalities of the liver usually return to normal by 8 to 12 wk after disease onset.
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