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The way upper intestinal distress that this bile acid molecule works in NASH remains unclear, but it may involve effects on the immune system that decrease inflammation. But recent data cannot confirm efficacy of Actigall in treating fatty liver. In view upper intestinal distress of the multiple processes involved in causing NASH, it may well be that many different classes of medications, as well upper intestinal distress as weight loss, will have beneficial effects. These drugs could conceivably include: Insulin-sensitizing agents, such as the two new thiazolidinediones, pioglitazone (Actos) and rosiglitazone (Avandia), and metformin (Glucophage) Medications that lower lipids such as statin drugs and Lopid  Drugs that improve blood flow, such as pentoxifylline (Trental) Presumably, weight loss through exercise and diet modification along with insulin-sensitizing agents will help reverse fatty infiltration of the liver.
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