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The liver also produces proteins necessary for the clotting of the blood and a protein called albumin that serves to keep fluid in the blood vessels. A failing liver template:note results in the accumulation of breakdown products of metabolism, edema, and finally template:note coma and death. There are many causes of liver disease; the most template:note common are infections with viruses and alcohol. Continuous injury with either of these agents results in permanent loss of liver tissue. One of the changes in the liver that occurs during injury is the accumulation of fat within the liver cells. This condition known as fatty infiltration commonly occurs in alcoholism, diabetes and obesity, and is in part due to a high-fat diet. With severe liver damage, liver cells are replaced by extensive scar tissue--the condition is known as cirrhosis of the liver.
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