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1988 Dec;22(3):195-203. Links Hepatocyte and nuclear fatty and skinny areas and fatty infiltration of the liver in chronic alcoholic liver disease.Gonzalez-Reimers E, Brajin-Rodriguez MM, Batista-Lopez N, Santolaria-Fernandez F, Martinez-Riera fatty and skinny A, Essardas-Daryanani H.Departamento de Medicina Interna, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.In 117 patients affected by chronic alcoholic liver disease, we have histomorphometrically determined hepatocyte and nuclear areas, total amount of fat and total amount of fibrosis, comparing them with the following clinical and biochemical parameters: ascites, encephalopathy, jaundice, spiders, collateral circulation, fatty and skinny splenomegaly, prothrombin activity, serum albumin, gammaglobulin, bilirubin, ASAT, ALAT, GGT, leukocyte and platelet count, and daily consumption of ethanol. Both hepatocyte and nuclear areas closely correlated with most of the parameters indicative of hepatic function derangement, whereas fat amount correlated with them inversely, but positively with the daily consumption of ethanol.
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