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Based on these observations of a virtually constant association of lipolysosomes with excess lipid accumulation in liver cells we suggest that lysosomes probably play an important role in hepatic lipid metabolism and that various pathogenetic mechanisms may trigger their proliferation.PMID: 892368 [PubMed - indexed for MEDLINE] Display Summary Brief Abstract Citation MEDLINE XML fat ugly girls UI List LinkOut ASN.1 Related Articles Cited Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Gene (GeneRIF) Links Genome Links Project Links GENSAT Links GEO Profile Links HomoloGene Links fat ugly girls Nucleotide Links OMIA Links fat ugly girls OMIM (calculated) Links OMIM (cited) Links BioAssay Links Compound Links Compound via MeSH Substance Links Substance via MeSH PMC Links Cited in PMC PopSet Links Probe Links Protein Links SNP Links Structure Links UniGene Links UniSTS Links Show 5 10 20 50 100 200 500 Sort by Pub Date First Author Last Author Journal Send to Text File Printer Clipboard E-mail Order Write to the Help Desk NCBI | NLM | NIH Department of Health &

All: 1 plump pics Review: 0 1: Gastroenterology. 1977 Oct;73(4 Pt 1):651-4. Links Lipolysosomes in human liver: distribution in livers with fatty infiltration.Hayashi H, Winship DH, Sternlieb I.In this study we investigated whether lipolysosomes--lysosomes containing large plump pics lipid droplets--were present in livers of patients with various forms of hepatic injury. Organelles which displayed the same morphological characteristics and enzymatic activity as those originally described in the hamster and those found in the hepatocytes of patients with Wolman's or Wilson's disease were also found in hepatocytes of 13 of 14 randomly selected biopsy specimens from patients with minimal to severe fatty infiltration of the liver. The numbers and sizes of the lipolysosomes seemed to increase with the degree of fatty infiltration while their proportion in relation to the total number of lipid droplets remained below 5%.

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