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When the concentration of NADPH diet. is increased, so is the diet. conversion of T4 to T3, which finally results in an increased metabolic rate leading diet. to a greater loss of fat mass. In summary, Nazar and colleagues (1996) state that "the observed elevation in resting metabolic rate is casually connected with changes in the rate of thyroxine deiodination most probably associated with enhancement of glucose utilization and production of NADPH induced by addition of inorganic phosphates." In the first study, conducted by Nazar and colleagues (1996), thirty overweight women aged 31-46 years participated in an eight week weight-reduction program. The women were randomly divided into two groups. Group one received phosphate supplement during the first four weeks of the study and placebo (sugar pills) during the last four weeks, while group two received placebo the first four weeks and phosphate supplement the remaining four weeks.
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